Research advance in the role of stanniocalcin in the pathogenesis of renal cell carcinoma
10.16571/j.cnki.1008-8199.2016.02.019
- VernacularTitle:斯钙素在肾细胞癌发病机制中的作用研究进展
- Author:
Shiqiang SU
;
Shujian PANG
;
Shaogang WANG
- Publication Type:Journal Article
- Keywords:
Stanniocalcin;
Renal cell carcinoma;
Pathogenesis;
Tumor marker
- From:
Journal of Medical Postgraduates
2016;(2):210-213
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma (RCC) is one of the most lethal malignancies of the urinary system, however, its pathogenic mechanism is not clear.Stanniocalcin (STC) is a type of glycoprotein hormone with multiple biological functions.Recently, the role of STC in the pathogenesis of cancer is of intriguing interest, and many researches have been performed to clarify underlying mechanism. We emphasized the role of STC in the underlying mechanism of RCC progression, from the aspects of STC inducing hypoxia adaptation of tumor cells, promoting tumor angiogenesis, also promoting cell proliferation, apoptosis, invasion and metastasis, and inhibiting the immune response.Conclusively, STC could be used as both a promising biomarker for RCC diagnosis and a theraputic target of renal cell carcinoma.
