Advances in enrichment strategies for phosphoproteomics and appIication of phosphoproteomics in disease research
10.11665/j.issn.1000-5048.20160103
- VernacularTitle:磷酸化蛋白质组学富集策略进展及其在疾病研究中的应用
- Author:
Weixin WU
;
Jia YAN
;
Xiying TAN
;
Bo LI
;
Mengxiang SU
;
Fang YAN
;
Bin DI
- Publication Type:Journal Article
- Keywords:
phosphoproteomics;
enrichment strategy;
new material;
disease research
- From:
Journal of China Pharmaceutical University
2016;(1):19-29
- CountryChina
- Language:Chinese
-
Abstract:
Protein phosphorylation is one of the most common post-translational modifications (PTMs)in various organisms,which plays critical roles in the regulation of intracellular biological processes,such as cell prolifera-tion,signal transduction,metabolismis and tumorigenesis.However,the low abundance of phosphoprotein in the biological systems poses significant challenges of current analytical techniques.In order to further understand the phosphoproteomics,the roles of phosphorylated proteins in life process,discovery of biomarkers,diagnosis and treatment of disease,enrichment strategies of high efficiency have been developed,including the design of new nanomaterials and combination of a variety of analytical methods,et al.In this paper,we reviewed the develop-ment of enrichment strategies for phosphoproteomics and application of phosphoproteomics in disease.
