Expression pattern of MiR-146a and its correlation with antibody titers in human brucellosis
10.3969/j.issn.1000-484X.2016.02.019
- VernacularTitle:布病患者血清microRNA-146 a表达及其与抗体滴度的关系研究
- Author:
Jiuxuan YU
;
Xiaoyang XU
;
Shuangshuang LEI
;
Zeliang CHEN
;
Jiqiu WANG
;
Dali WANG
;
Yuanqiang ZHENG
;
Yanchun SHI
- Publication Type:Journal Article
- Keywords:
microRNA-146a;
Brucellosis;
Serum antibody titers
- From:
Chinese Journal of Immunology
2016;(2):230-233
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the expression pattern of microRNA-146a in Brucella patients and its correlation with antibody titers.Methods: By using real time PCR assay, expression levels of microRNA-146a in sera samples from 20 brucellosis patients and 20 healthy volunteers were analyzed.The correlation between expression level of microRNA-146a and serum antibody titers were analyzed with SPSS17.0.Results: A quantification curve of microRNA-146a was constructed with synthesized standard.Expression levels of microRNA-146a among brucellosis patients were significantly lower than those in 20 healthy volunteers (P<0.001).For brucellosis patients,the expression level of microRNA-146a was negatively related with antibody titers (P<0.05). Conclusion:Expression of miRNA-146a in brucellosis patients was significantly inhibited and negatively related with antibody titer.
