Systematic review and meta-analysis about efficacy of azithromycin in lung function of patients with idiopathic pulmonary fibrosis
- VernacularTitle:阿奇霉素对特发性肺间质纤维化患者肺功能影响的系统评价及 Meta 分析
- Author:
Chaofeng CHEN
;
Yali WU
;
Yuqiong ZHENG
- Publication Type:Journal Article
- Keywords:
Azithromycin;
Idiopathic pulmonary fibrosis;
Lung function
- From:
Journal of Chinese Physician
2015;(z2):16-19
- CountryChina
- Language:Chinese
-
Abstract:
Objective The study was designed to evaluate the clinical efficacy of azithromycin in lung function of patients with IPF.Methods Randomized controlled trials were searched in CNKI,data-base of Wanfang and WeiPu,where azithromycin was used to patients with IPF.We extracted all data on lung functions,standardized mean difference (SMD)with 95% confidence intervals (CI )were pooled with Stata 11.0.Results Seven unique trials with 516 participants were identified.Be compared to pred-nisone,the patients with IPF received azithromycin experienced no improvement in FVC% [SMD = -2.00,95% CI =(-2.05,-1.95)],but it was found that azithromycin was superior to prednisone in in-crease the percentage of carbon monoxide diffusing [SMD =1.16,95% CI =(-2.83,5.16)]and de-cline the percentage of residual volume[SMD =3.00,95% CI =(1.04,4.96)].Azithromycin combined with prednisone were statistically superior to prednisone alone in improvement of FEV1 %[SMD =7.80, 95% CI =(5.92,9.67)],FVC%[SMD =7.23,95% CI =(4.89,7.56)]and lung carbon monoxide diffusion function[ml/(min·kpa))][SMD =40.62,95% CI =(38.96,42.28)].Conclusions Our study suggests that azithromycin significantly improvement pulmonary diffusion function in patients with IPF. Azithromycin combined with prednisone were more effective in improvement of FEV1 %,FVC% and lung diffusion function.
