Role of microRNA-506 in different tumors
10.3969/j.issn.1000-8179.2016.03.337
- VernacularTitle:microRNA-506在不同肿瘤中作用的研究进展
- Author:
Jingyi ZHANG
;
Yan SUN
- Publication Type:Journal Article
- Keywords:
microRNA-506;
tumor;
tumor suppressor;
targeted therapy
- From:
Chinese Journal of Clinical Oncology
2016;(3):120-124
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA-506 (miRNA-506) is located in the X chromosome and influences various processes, such as cell proliferation, apoptosis, senescence, cell cycle, cell differentiation, epithelial-to-mesenchymal transition, angiogenesis, invasion, and metastasis, through post-transcriptional regulation of its targets. Recent studies have shown that miRNA-506 plays an important role in tumorigen-esis and progression of many types of tumors. In vitro and in vivo experiments revealed that miRNA-506 suppresses progression of sev-eral tumors and promotes response of tumor cells to chemotherapy. However, miRNA-506 plays different roles in different tumors. This review summarizes the functions and mechanisms of miRNA-506 in different tumors to identify a new target for the targeted ther-apy of certain tumors.
