Advances in virus-based therapies for colorectal cancer
10.3969/j.issn.1000-8179.2016.03.301
- VernacularTitle:应用病毒治疗结直肠癌的研究进展
- Author:
Lei YIN
;
Yanlai SUN
;
Zhongfa XU
- Publication Type:Journal Article
- Keywords:
colorectal neoplasm;
oncolytic virus;
viral vector;
genetic therapy;
immunotherapy
- From:
Chinese Journal of Clinical Oncology
2016;(3):125-129
- CountryChina
- Language:Chinese
-
Abstract:
Virus-based anti-tumor therapies are novel biological treatments. Viral vectors can infect tumors to kill cancers directly (on-colysis), act as cancer vaccines to activate the immune system, and deliver genes with anti-tumor activity to the cancer cells. Genetic engineering has been applied to viruses to achieve more specific and efficient cancer treatment. Simultaneously, a reasonable combi-nation of viral vectors and existing anti-tumor therapy can improve the therapeutic effect. Consequently, virus-based therapy is expect-ed to serve as an effective anti-tumor strategy. We reviewed recent studies on the anti-tumor viral therapy of colorectal carcinoma.
