Resae rch advances of HBV mous e model and liver immunology
10.3969/j.issn.1000-484X.2016.02.001
- VernacularTitle:HBV小鼠模型与肝脏免疫学研究进展
- Author:
Fenglei LI
;
Xiaolei HAO
;
Zhigang TIAN
- Publication Type:Journal Article
- Keywords:
Hepatitis B virus;
Mouse model;
Transgenic;
Humanized mouse;
Viral immunology
- From:
Chinese Journal of Immunology
2016;(2):145-153
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus ( HBV) threatens human's health seriously, immune disorder is the main pathogenesis.HBV cannot naturally infect mouse liver, thus the researchers tried to established HBV mouse models to imitate the immunological pathogenesis of HBV infection.This review summarize various methods to establish HBV mouse models, including HBV transgenic technics, HBV in vivo liver-target transfection technics and HBV naturally infected humanized mouse technics etc.Their advantages, disadvantages and contributions to immunological studies were also analyzed, and the development of this area was also prospected.
