Relationship between rheumatoid arthritis and risk of vertebral fractures
10.3969/j.issn.1000-484X.2016.02.018
- VernacularTitle:类风湿关节炎患者罹患椎体骨折危险的Meta分析
- Author:
Yan XIA
;
Yang XIANG
;
Jia FENG
;
Nianan YANG
;
Anping CHEN
;
Yufang DAI
;
Lin YUAN
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Vertebral fractures/deformities;
Meta-analysis
- From:
Chinese Journal of Immunology
2016;(2):226-229
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize the evidence for the link between rheumatoid arthritis and risk of vertebral fractures or vertebral deformities with a meta-analysis, so as to provide objective proof for early preventing and the development of vertebral deformity and fractures.Methods:Wanfang,CNKI,VIP,PUBMED,Springlink and Elsevier were retrieved for all publications relating to rheumatoid arthritis and vertebral fractures in women.According to inclusion and exclusion criteria,two investigators collected their data individually,then statistical analysis was performed using Stata 12.0 software.Results: Eight case-control studies were enrolled, including 86 741 participants,2 258 of them with RA.The results of Meta-analysis showed that a higher incidence of vertebral fractures in RA,and Odds ratio was 3.70 with a 95%confidence interval(2.47-5.55,P<0.000 1).The publication bias analysis did not reveal any evidence of obvious asymmetry, and the sensitivity analysis showed that omission of any individual study made no significant difference for all comparison models,suggesting that our results were statistically robust.Conclusion:RA may be one of the risk factors for the vertebral fractures.
