Expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clini-copathological characteristics and prognosis
10.3969/j.issn.1000-8179.2016.02.211
- VernacularTitle:MUC15和PI3K/Akt表达与胃癌临床病理特征及预后的相关性研究
- Author:
Zhiwei HAN
;
Ruizhou RONG
;
Pengzhou KONG
;
Caixia CHENG
;
Yanyan ZHANG
;
Jinyao DONG
;
Shujing LI
;
Jiansheng GUO
- Publication Type:Journal Article
- Keywords:
gastric carcinoma;
immunohistochemistry;
MUC15;
PI3K/Akt;
prognosis
- From:
Chinese Journal of Clinical Oncology
2016;(2):56-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the expression of MUC15 and PI3K/Akt in gastric carcinoma and its association with clinicopathologi-cal characteristics and prognosis. Methods:The expression of MUC15 and Akt was detected in 144 cases of gastric carcinoma tissues and corresponding para-carcinoma tissues by tissue microarray and immunohistochemistry. Results:The positive expression rate of MUC15 in gastric carcinoma was 79.8%, higher than that of para-carcinoma tissues (22.2%, P<0.01). The positive expression rate of Akt protein in gastric carcinoma was 80.6%, higher than that of para-carcinoma tissues (16.7%, P<0.01). The expression of MUC15 and Akt was statistically associated with the grades of differentiation, invasion depth, lymphatic metastasis, TNM stage of tumor tissues (P<0.05), and the positive correlation between the two protein expression that appear in the gastric tumor tissue (P=0.001). Univariate survival analysis showed that the over-expression of either MUC15 or Akt was inversely correlated with the survival time (P<0.05 and P<0.01, respectively). Cox multiple regression analysis indicated that patients with over-expression of both MUC15 and Akt had the worst prognoses (HR=3.115, P<0.05). Conclusion:MUC15 may be involved in the occurrence, development, invasion, and metastasis of gastric cancer through the PI3K/Akt cell signaling pathway, and the expression of MUC15 combined with Akt is a powerful predictor for the prognosis of gastric cancer.
