Analysis of the maintenance treatment and prognostic factors of metastatic colorectal cancer patients with stable disease symptoms after induction chemotherapy
10.3969/j.issn.1000-8179.2016.02.172
- VernacularTitle:维持治疗在晚期结直肠癌化疗后达稳定患者中的价值及预后分析
- Author:
Xingyun CHEN
;
Likun ZHOU
;
Xia WANG
;
Ming BAI
;
Rui LIU
;
Hongli LI
;
Yi BA
;
Dingzhi HUANG
- Publication Type:Journal Article
- Keywords:
metastatic colorectal cancer;
stable disease;
survival;
prognosis
- From:
Chinese Journal of Clinical Oncology
2016;(2):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the survival and individualized therapy of metastatic colorectal cancer (mCRC) patients who achieved a stable disease state after induction chemotherapy. Methods:Data were reviewed from 204 metastatic colorectal cancer pa-tients, who presented a stable disease state after first-line and second-line chemotherapy at Tianjin Medical University Cancer Insti-tute and Hospital. The clinical and pathological characteristics were analyzed. Moreover, we analyzed the significance of maintenance treatment in patients with certain mCRC characteristics. Results:Univariate analysis indicated that the line of chemotherapy, levels of CA724, CEA, and CA19-9, and platelet-to-lymphocyte ratio (PLR) were considered prognostic factors of treatment after induction che-motherapy. According to the multivariate analysis, first-line chemotherapy, as well as low levels of CA19-9 and PLR, with maintenance treatment after the induction chemotherapy was significantly associated with better survival. Among the patients with high levels of PLR, those who underwent maintenance treatment achieved a progression-free survival of 13.43 months (versus 10.63 months in pa-tients from the observation group, P=0.003). Conclusion:The levels of CA19-9 and PLR, and treatment after chemotherapy were signif-icant prognostic factors for mCRC patients who achieved a stable disease state after induction chemotherapy. These patients, especial-ly those with high PLR, could benefit from the maintenance treatment.
