Clinicopathological features and risk factors for central compartment nodal metastasis in papillary thyroid microcarcinoma:a study of 1 401 patients
10.3969/j.issn.1000-8179.2016.2016.03.187
- VernacularTitle:1401例甲状腺微小乳头状癌临床病理特征及中央区淋巴结转移危险因素分析
- Author:
Chen PENG
;
Songfeng WEI
;
Xiangqian ZHENG
;
Yang YU
;
Yan ZHANG
;
Wenyuan CHENG
;
Ming GAO
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
papillary microcarcinoma;
central compartment lymph node;
lymphatic metastasis;
risk factors
- From:
Chinese Journal of Clinical Oncology
2016;(3):95-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To determine the clinical features of papillary thyroid microcarcinoma (PTMC) and the risk factors for central compartment lymph node (CCLN) metastasis in PTMC. Methods:Data of 1 401 patients with PTMC who were treated in Tianjin Medi-cal University Cancer Institute and Hospital between January 2014 and December 2014 were retrospectively analyzed. Chi-square test and multivariate Logistic regression analysis were used to study the risk factors. Results:With regard to clinicopathological features, the sex ratio is 1:3.4 in patients with PTMC. CCLN metastasis affected 427 (30.5%) of the total 1 401 patients. Age (χ2=14.587, P<0.01), sex (χ2=21.636, P<0.01), tumor multifocality (χ2=35.505, P<0.01), tumor size (χ2=58.868, P<0.01), tumor site (χ2=8.385, P<0.05), and extracapsular/extraglandular invasions (χ2=26.481, P<0.01) were significantly correlated with CCLN metastasis. For patients with a soli-tary primary tumor, tumor location in the lower third of the thyroid lobe was associated with a higher risk of CCLN metastasis (48.1%). The male gender, age<45 years, tumor size>6 mm, extracapsular spread, and tumor bilaterality were independently correlated with CCLN metastasis. Conclusion:A prophylactic neck dissection of the central compartment must be considered particularly in male PT-MC patients with age<45 years, tumor size>6 mm, extracapsular spread, and tumor bilaterality.
