Application value of fetal umbilical cord blood hemoglobin analysis in prenatal diagnosis of thalassemia
10.3969/j.issn.1673-4130.2016.03.004
- VernacularTitle:胎儿脐带血血红蛋白分析在珠蛋白生成障碍性贫血产前诊断中的应用价值
- Author:
Tianwen HE
;
Yixia WANG
;
Hao GUO
;
Tenglong YUAN
;
Mingyong LUO
;
Li DU
- Publication Type:Journal Article
- Keywords:
umbilical cord blood;
hemoglobin analysis;
thalassemia;
prenatal diagnosis
- From:
International Journal of Laboratory Medicine
2016;(3):297-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of fetal umbilical cord blood hemoglobin analysis in the prenatal diag ‐nosis of thalassemia .Methods 113 couples were the carriers of the same gene type of thalassemia ,moreover the females were in the pregnant period of 24 - 30 pregnant weeks and performed the prenatal diagnosis .The fetal umbilical cord blood hemoglobin compo‐nents were analyzed by the full automatic capillary electrophoresis technique ,meanwhile the fetal thalassemia gene was detected .Re‐sults Among 113 fetuses ,the umbilical cord blood HbBart′s level in 11 cases of severe α thalassemia was 85 .0% - 95 .5% ,which in 9 cases of intermediate type α thalassemia was 22 .0% - 39 .5% ;the umbilical cord blood HbA level in 6 cases of severe β thalas‐semia was 0% - 0 .4% ,which in 17 cases of light type β thalassemia was 2 .1% - 12 .5% .Conclusion The fetal umbilical cord blood hemoglobin analysis could be used for rapid prenatal diagnosis of severe α ,β and intermediate type α thalassemia ,which can serve as a supplementary method for the prenatal diagnosis of thalassemia .
