Clinical research about liver function of hepatolenticular degeneration combined liver fibrosis by transplantation of bone marrow stem cells
10.3969/j.issn.1000-484X.2016.02.010
- VernacularTitle:骨髓间充质干细胞对肝豆状核变性合并肝纤维化肝功能的临床研究
- Author:
Dongfeng ZHANG
;
Yushu WANG
;
Junfang TENG
- Publication Type:Journal Article
- Keywords:
Hepatolenticular degeneration;
Liver function;
Bone marrow stem cells;
Penicillamine
- From:
Chinese Journal of Immunology
2016;(2):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the influence of bone marrow stem cells ( BMSCs ) in the serological indicators of hepatolenticular degeneration combined liver fibrosis.Methods:60 cases were randomly divided into 3 groups: penicillamine group, BMSCs group and BMSCs+penicillamine group.BMSCs(2 ml)were injected into vein with normal saline(100 ml) every 10 days ( 3 times for a period of treatment).Liver tissue pathology biopsy was inspected and TBIL, ALT, ALB, CHE, PDGF-BB, TGF-β1, IL-6 and TNF-αwere detected at 0,4 ,8 and 12 weeks.Results: The level of serological indicators about liver functions were reduced in every group, while the changes in BMSCs+penicillamine group were especially obvious ( P<0.05 ).Conclusion: Penicillamine combined with BMSCs was effective in the improvement of liver functions of hepatolenticular degeneration combined liver fibrosis.
