Study on design and three-dimension structure of a broad-spectrum inhibitory peptide against staphylococcal enterotoxins superantigen
10.3969/j.issn.1000-484X.2016.02.011
- VernacularTitle:葡萄球菌肠毒素超抗原广谱抑制性多肽的设计及空间结构研究
- Author:
Sixiong WANG
;
Huiwen MA
;
Donglin WANG
- Publication Type:Journal Article
- Keywords:
Staphylococcal enterotoxin;
Superantigen;
Synthetic peptide
- From:
Chinese Journal of Immunology
2016;(2):197-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Peptides were designed on the basis of high conservative regions of amino acid sequences and structures of the SEs,three-dimension structure of P72 was constructed.Methods: Bioinformatics analysis softwares such as Vector NTI 10.3, InsightII 2000,Discovery Studio 1.7 were used to analyse and predict the space structure of P72.Results:three-dimensional domains of the peptide P72 from SEA, SEB and SEC were quite similar, Peptide P72 was far away from TCRVβchain and MHC class II molecule.Conclusion:The inhibitory activity of peptide P72 may not due to binding to MHCⅡ and TCRVβchain.The exact mechanism of inhibitory activity of P72 should be explored.
