Expression and significance of HSPC238 in cervical intraepithelial neoplasia and cervical cancer
10.3969/j.issn.1000-484X.2016.02.017
- VernacularTitle:HSPC238在宫颈上皮内瘤变和宫颈癌中的表达与意义
- Author:
Yuheng ZHONG
;
Xiang HUANG
;
Jinglin CHEN
;
Jiayu TAN
;
Xianjun MI
;
Xiangyu LIU
- Publication Type:Journal Article
- Keywords:
HSPC238;
Cervical cancer;
Cervical intraepithelial neoplasia;
Immunohistochemistry
- From:
Chinese Journal of Immunology
2016;(2):223-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the expression of HSPC238 in cervical intraepithelial neoplasia and cervical cancer.Methods:We collected 76 cases of cervical cancer,105 cases of CIN and 28 cases of normal cervical epithelial.Then we inves-tigated the expression of HSPC238 by using immunohistochemistry and compared the significant differences between them.Results:There was no significant difference in the expression of HSPC238 between the cervical cancer and normal cervical epithelial ( Z=-0.242,P>0.05).However,there was significant difference between the cervical intraepithelial neoplasia and normal cervical epithelial (χ2=19.159,P<0.01) and the expression of HSPC238 was correlated with the grades of CIN.The expression of HSPC238 decreased when the grade of CIN was increasing.( rs=-0.327,P<0.01 ).Conclusion:The low expression of HSPC238 might be correlated with the development of cervical neoplasia.
