Bone morphogenetic protein-2 carrier materials in the spinal fusion
10.3969/j.issn.2095-4344.2015.52.022
- VernacularTitle:骨形态发生蛋白2载体材料在脊柱融合方面的研究与应用
- Author:
Jie JIANG
;
Liang CHEN
;
Yong GU
;
Zhan PENG
- Publication Type:Journal Article
- From:
Chinese Journal of Tissue Engineering Research
2015;(52):8487-8491
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: There are some adverse reactions when bone morphogenetic protein-2 is applied independently in clinic; therefore, it is urgent to develop an ideal carrier material to reduce the incidence of adverse reactions induced by bone morphogenetic protein-2. OBJECTIVE:To comprehensively understand the performance of different kinds of bone morphogenetic protein-2 carrier materials, and to summarize their research progress in the field of spinal fusion. METHODS:The literatures about bone morphogenetic protein-2 scaffolds in spinal fusion were retrieved by the first author from PubMed and Wanfang datebase durings July 1, 1995 to July 1, 2015 with the key words of“tissue engineering, bone morphogenetic protein-2, spinal fusion, scaffold” in English and Chinese, respectively. Repetitive studies were excluded. RESULTS AND CONCLUSION:Bone morphogenetic protein-2 carrier materials mainly include four categories: natural biological materials, synthetic organic materials, synthetic inorganic materials and composite materials, each of which has several representative scaffold materials. Each category has their own shortcomings when applied in animal spinal fusion, for instance, the mechanical properties of natural biological materials are generaly poor; synthetic organic materials may cause inflammatory reactions; the mechanical strength of synthetic inorganic materials is poor and the production process of composite materials is relatively complicated. Therefore, the selection of bone morphogenetic protein-2 carrier materials stil needs further experimental study.
