Research progress in radiation-induced organ fibrosis
10.7644/j.issn.1674-9960.2016.01.016
- VernacularTitle:放射性器官纤维化的分子机制及靶向治疗研究进展
- Author:
Yanfeng WANG
;
Huihua CHEN
;
Hang SU
- Publication Type:Journal Article
- Keywords:
radiation;
fibrosis;
transforming growth factor;
connective tissue growth factor;
targeted therapy
- From:Military Medical Sciences
2016;(1):74-78
- CountryChina
- Language:Chinese
-
Abstract:
Radiation-induced organ fibrosis is a common complication of tumor radiotherapy and radiation accident, which poses a serious threat to patients′life.TGF-β, CTGF, PDGF-BB and NF-κB all play important roles in this pathological process, and drugs targeting these key molecules are also being developed, some of which have shown positive therapeutic effects.This review focuses on the molecular mechanisms and therapeutic progress involved in radiation-induced organ fibrosis, intended to provide a new clue to the complex process of radiation-induced organ fibrosis, and to provide a new strategy for treatment.
