Clinicopathological significance of PTEN protein expression in breast cancer:a Meta-analysis
10.3969/j.issn.1671-8348.2016.03.030
- VernacularTitle:PTEN蛋白表达与乳腺癌患者临床病理学特征相关性的 Meta分析
- Author:
Cheng FANG
;
Xinghua LONG
- Publication Type:Journal Article
- Keywords:
breast neoplasms;
tumor suppressor proteins;
PTEN;
estrogen receptor;
clinicopathological features;
Meta-analy-sis
- From:
Chongqing Medicine
2016;(3):383-386
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between the expression of PTEN protein and the clinicopathological char‐acteristics of breast cancer patients .Methods All eligible studies regarding the association of PTEN protein expression with clini‐copathological features in patients with breast cancer were retrieved from PubMed ,Embase ,Cochrane Library ,CNKI and Wanfang databases .Odds ratio(OR) with corresponding 95% confidence interval(95% CI) form eligible studies were pooled .Heterogeneity and publication bias were also evaluated .All analyses were operated using RevMan 5 .2 software .Results A total of 28 articles con‐taining 3 172 patients were ultimately included for this Meta‐analysis .Our findings revealed that the expression level of PTEN was significantly correlated with estrogen receptor status(OR= 3 .16 ,95% CI:2 .01 -4 .97 ,P< 0 .01) ,progesterone receptor status (OR=2 .27 ,95% CI:1 .70 -3 .04 ,P<0 .01) ,lymph node metastasis(OR=0 .36 ,95% CI :0 .27 -0 .49 ,P<0 .01) ,clinical stage (OR=2 .59 ,95% CI:2 .04-3 .30 ,P<0 .01) and histological grade(OR=2 .19 ,95% CI:1 .74-2 .75 ,P<0 .01) .Conclusion Aber‐rant PTEN expression might have strong impacts on carcinogenesis ,tumor progression ,invasion and prognosis ,which makes it a potential biomarker for early cancer screening and endocrine therapy in breast cancer .
