STAT3 signaling in pathogenesis of pancreatitis
10.3969/j.issn.1000-4718.2016.03.029
- VernacularTitle:STAT3信号转导在胰腺炎发病机制中的作用
- Author:
Linfei ZONG
;
Xiaohui XIANG
;
Shihai XIA
- Publication Type:Journal Article
- Keywords:
Signal transducer and activator of transcription 3;
Acute pancreatitis;
Chronic pancreatitis;
Cy-tokines
- From:
Chinese Journal of Pathophysiology
2016;32(3):558-563
- CountryChina
- Language:Chinese
-
Abstract:
Signal transducer and activator of transcription 3 (STAT3), an acute-phase response protein, is ac-tivated to over-express by cytokines .STAT3 also acts as a transcriptional factor to regulate the expression of cytokines .O-ver-expression of cytokines is accompanied by STAT 3 activation and over-expression in acute pancreatitis .Meanwhile , the proliferation of pancreatic stellate cells in chronic pancreatitis is mediated by STAT 3.In this review, the research progress in STAT3 function is summarized to elaborate its potential role in the pathogenesis of pancreatitis .
