Development of Tim-3 and gastrointestinal tumors
10.16571/j.cnki.1008-8199.2016.04.021
- VernacularTitle:T细胞免疫球蛋白黏蛋白分子-3与消化道肿瘤的研究进展
- Author:
Wen YE
;
Fucai WANG
;
Nanjin ZHOU
;
Yong XIE
- Publication Type:Journal Article
- Keywords:
T cell immunoglobulin domain and mucin domain protein-3;
Gastrointestinal tumors;
T cell;
NK cell;
Mononu-clear macrophage
- From:
Journal of Medical Postgraduates
2016;29(4):435-439
- CountryChina
- Language:Chinese
-
Abstract:
As an inhibitory receptor , T cell immunoglobulin mucin domain containing molecules-3 ( Tim-3 ) expresses high levels in the gastrointestinal tumor microenvironment .Tim-3 can promote T cell exhaustion , negatively regulate the anti-cancer immuni-ty of NK cell and induce polarization of macrophages to M 2.Tumor can escape from immunological surveillance through Tim-3.Tim-3 plays an important role in the development and transformation of gastrointestinal tumors .This article summarizes the role of Tim-3 in the gastrointestinal tumors from the aspects of gene polymorphism , T cells, NK cells and mononuclear macrophage .
