Clinical effect of escitalopram oxalate in treating patients with depression accompanied with anxiety disorder
10.3760/cma.j.issn.1008-6706.2016.04.030
- VernacularTitle:草酸艾司西酞普兰治疗抑郁症伴发焦虑症的临床疗效分析
- Author:
Xiaoqing WANG
;
Weiqing CHEN
- Publication Type:Journal Article
- Keywords:
Depression;
Escitalopram oxalate;
Anxiety disorder;
Clinical effect
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;(4):598-602
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effect of escitalopram oxalate in treating patients with depression accompanied with anxiety disorder.Methods Sixty-four patients with depression accompanied with anxiety disorder (met DSM-IV diagnostic criteria)were randomly divided into study group (n =32)who were treated with escitalo-pram oxalate 5-20mg/d and control group (n =32)with mirtazapine 15-45 for eight weeks.Clinical effect was evalua-ted with the Hamilton Depression Scale (HAMD)and the Hamilton Anxiety Scale (HAMA)as well as the adverse reactions with the Treatment Emergent Symptom Scale (TESS).Results There were no statistically significant differ-ences (P >0.05)in HAMD and HAMA scores between the study group and control group before treatment,but after treatment for 8 weeks,HAMD score showed statistically significant difference (P =0.000)and the difference of HAMA score was statistically significant (P =0.010).The total effective rate of the study group was 93.8%,which of the control group was 87.5%,the clinical effect had no statistically significant difference (P =0.391 ).The study group and the control group had equal effect,and there were no serious adverse reactions.Conclusion Escitalopram oxalate has high anti-depressant and anxiolytic effect,fewer adverse reactions,good tolerability and compliance,there-fore,escitalopram oxalate can be popularized in treating patients with depression accompanied with anxiety disorder.
