Role of fibroblasts in the development of atrial fibrillation
10.16571/j.cnki.1008-8199.2016.02.020
- VernacularTitle:成纤维细胞在心房纤颤发生中的作用机制
- Author:
Qing WANG
;
Yunyan ZHANG
;
Zhinong WANG
- Publication Type:Journal Article
- Keywords:
Fibroblast;
Atrial fibrosis;
Atrial remodeling;
Atrial fibrillation
- From:
Journal of Medical Postgraduates
2016;(2):214-217
- CountryChina
- Language:Chinese
-
Abstract:
Influenced by a variety of pathologic factors, cardiac fibroblasts can transdifferentiate into myofibroblasts and pro-liferate excessively, followed by an overdue secretion of extracellular matrix ( ECM) .This process involves complicated signaling path-ways and electrophysiological mechanisms and may result in atrial fibrosis and contribute to atrial remodeling in structure, function and electrophysiological signaling, which is considered as a most important phase of atrial fibrillation.This review focuses on the role of fi-broblasts in atrial fibrosis, atrial remodeling, and the development of atrial fibrillation.
