Expression and Significance of Notch1 in Human Gastric Cancer
10.3969/j.issn.1008-7125.2016.01.007
- VernacularTitle:人胃癌组织 Notch1表达及其意义
- Author:
Li CHU
;
Chenxiao CAI
;
Xinguang YIN
;
Wanxin WU
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Notch1;
Immunohistochemistry;
Helicobacter pylori
- From:
Chinese Journal of Gastroenterology
2016;(1):30-33
- CountryChina
- Language:Chinese
-
Abstract:
Background:Gastric cancer(GC)is the fourth commonly seen cancer in the world. The role of Notch signaling pathway in the pathogenesis of tumors has become a focus in related studies,however,the underlying mechanism of Notch1 in GC has not yet been fully understood. Aims:To investigate the expression and significance of Notch1 in human GC tissue. Methods:A total of 115 patients with GC admitted at Jiaxing First Hospital from October 2011 to July 2014 were enrolled. Expression of Notch1 in cancerous tissue and para-cancer noncancerous tissue was determined by immunohistochemistry. The correlation between expression of Notch1 and clinicopathological characteristics of GC was analyzed. Results:Expression rate of Notch1 in cancerous tissue was significantly higher than that in para-cancer noncancerous tissue(73. 9% vs. 3. 5% ,P < 0. 001). Notch1 expression in cancerous tissue was significantly correlated with depth of vascular involvement,lymph node metastasis and TNM stage of GC(P < 0. 05). Conclusions:Notch1 as a cancer-promoting gene is involved in the pathogenesis of GC,and has a close association with tumor invasion and metastasis.
