Effects of cinnamaldehyde on aspergillus fumigatus biofilm in vitro
10.3969/j.issn.1671-8348.2016.03.012
- VernacularTitle:肉桂醛对烟曲霉菌体外生物膜的影响
- Author:
Lihong WU
;
Yiqiang CHEN
;
Jinliang KONG
;
Jing LUO
;
Hong HUANG
;
Changchun HOU
- Publication Type:Journal Article
- Keywords:
cinnamomum cassia;
aspergillus fumigatus;
biofilm;
cinnamaldehyde
- From:
Chongqing Medicine
2016;(3):326-328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the treatment effect of cinnamaldehyde on Aspergillus fumigatus biofilm(BF) in vitro .Meth‐ods The models of A .fumigatus BF were established in vitro ;the minimum inhibitory concentration(MIC) on A .fumigatus was measured .The crystal violet assay and scanning electron microscopy were employed to determined the treatment effect of A .fumiga‐tus biofilm under varying concentrations of cinnamaldehyde .Results BF models were established successfully in vitro .MIC value of A .fumigatus of cinnamaldehyde was 256 μg/mL ;The biofilm biomass in serially increasing concentrations of cinnamaldehyde(1 MIC ,1/2 MIC ,1/4 MIC)were 0 .81 ± 0 .11 ,1 .13 ± 0 .18 and 1 .59 ± 0 .11 respectively .Compared to untreated control group(2 .18 ± 0 .15) ,difference achieved statistical significance(P<0 .05) .SEM studies revealed the deformity of three‐dimensional structures of biofilms treated with sub‐MICs of cinnamaldehyde .Conclusion Cinnamaldehyde has significant antifungal activity against Aspergil‐lus fumigatus ,sub‐MICs could disrupt the mature biofilm in vitro .
