Expression of transcription factor Sp3 in hepatocellular carcinoma
10.3969/j.issn.1671-8348.2016.03.022
- VernacularTitle:转录因子S p3在肝细胞癌中的表达意义
- Author:
Weijia MO
;
Jia LI
;
Huiping LU
;
Zhenbo FENG
- Publication Type:Journal Article
- Keywords:
carcinoma,hepato cellular;
liver neoplasms;
transcription factor Sp3;
β-Catenin
- From:
Chongqing Medicine
2016;(3):356-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the expression of Sp3 andβ‐Catenin in HCC and study the assessable factors of them for prognosis in patients with hepatocellular carcinoma .Methods Western blot and RT‐PCR methods were used to detect the expres‐sion of Sp3 andβ‐Catenin in HCC and the liver tissue beside tumor among 49 cases .We analyzed the difference of these two indexes expressed in HCC and the liver tissue beside tumor .Then we detected the correlation between these two indexes and the character of clinic pathology ,and researched the correlation between Sp3 and the prognosis of HCC .Results The high expression rate of Sp3 in HCC was higher than that of liver tissue beside tumor(P<0 .05) according to Western blot and RT‐PCR ,the same toβ‐Catenin (P<0 .05) .Expression of Sp3 andβ‐Catenin were both related with size of tumor and degree of differentiation .Positive correlation existed between these two indexes according to Western blot method(r=0 .681 ,P=0 .000) and RT‐PCR method(r=0 .641 ,P=0 .000) .The prognosis of cases with high expression of Sp3 was poorer than the low expression cases(P<0 .05) .Conclusion Sp3 plays a promoter role in occurrence of HCC ,which is correlated with the grade malignancy of HCC .Sp3 might participated in occur‐rence and development of HCC via the Wnt pathway .
