The value of thromboelastography in evaluating the risk of bleeding in patients with acute leukemia
10.3969/j.issn.1671-8348.2016.03.025
- VernacularTitle:血栓弹力图对急性白血病患者出血风险的预测价值研究
- Author:
Mei ZHAO
;
Shu CHEN
;
Shifeng LOU
;
Jianchuan DENG
;
Kang ZHOU
- Publication Type:Journal Article
- Keywords:
thrombelastography;
leukemia;
acute disease;
hemorrhage
- From:
Chongqing Medicine
2016;(3):369-371
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of thrombelastography(TEG) in assessing the risk of bleeding and diagnostic value in patients with acute leukemia(AL) .Methods The TEG and PLT data were counted in 127 patients(272 sets of data) who were diagnosed with AL .Those patients were divided into two groups :group 1 (including patients with bleeding) and group 2 (in‐cluding patients with no bleeding) .The indicators(R values ,K values ,α‐angle ,MA values)and PLT count were compared between two groups .Those data with PLT<30 × 109/L of these two groups also were divided and the 4 indicators of TEG were compared between the two groups .We used the ROC curve to evaluate the sensitivity and specificity in assessing the risk of bleeding .Results According to the data in total ,the K value ,R value of the group 1 were higher than those of the group 2(P<0 .05);theα‐angle and MA value ,PLT counts of group 1 were lower than those of the group 2(P<0 .05) .In those AL patients whose PLT<30 × 109/L ,the K value of the group 1 was higher than that of the group 2(P<0 .05);theα‐Angle and MA value of the group 1 were lower than those of the group 2(P<0 .05);R values and PLT count were not different between the two groups(P>0 .05);the are‐as under the ROC curve about the PLT counts ,MA value andα‐angle were more than 0 .5 (0 .750 ,0 .740 and 0 .653) .Conclusion T EG could predict the risk of bleeding in acute leukemia patients and it could be used in clinical application .
