Expression and significance of miR-145 in acute myeloid leukemia
10.3969/j.issn.1671-8348.2016.03.028
- VernacularTitle:MicroRNA-145在急性髓系白血病患者中的表达及意义
- Author:
Heyan ZHU
;
Huihui LI
- Publication Type:Journal Article
- Keywords:
acute disease;
bone marrow cells;
leukemia;
microRNAs;
acute myeloid leukemia;
miR-145
- From:
Chongqing Medicine
2016;(3):377-379
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the expression and clinical significance of miR‐145 in the marrow of acute myeloid leuke‐mia (AML) .Methods A total of 70 cases of bone marrow samples were collected from AML patients ,of which included 46 cases of new diagnosed patients(initial treatment group) ,24 cases of AML patients in complete remission(remission group) .Fourteen ca‐ses of non‐neoplastic patients were used as controls(control group) .The miR‐145 relative expression level was detected by real‐time quantitative PCR .Results The relative expression level of miR‐145 in initial treatment group was less than those of control group and remission group(P<0 .01) .Compared to before‐chemotherapy patients ,the expression level of miR‐145 in the 9 case of AML patients with complete remission after chemotherapy increased significantly(P<0 .05) .The relative expression of miR‐145 showed no significantly correlation with the percentage of blasts cells in bone marrow and the percentage of peripheral blood leukocyte count (P=0 .456 ,0 .394) .Conclusion The expression of miR‐145 in bone marrow cells of AML patients is down‐regulated ,which sug‐gested the development of acute leukemia .
