Molecular mechanisms of dental fluorosis
10.3760/cma.j.issn.2095-4255.2016.01.020
- VernacularTitle:氟斑牙发生的分子机制的研究现状
- Author:
Rui PENG
;
Ling LI
;
Xiaoyan GUAN
;
Jiayuan WU
;
Jianguo LIU
- Publication Type:Journal Article
- Keywords:
Fluorine;
Fluorosis,dental;
Molecular Mechanisms of Action
- From:
Chinese Journal of Endemiology
2016;(1):71-74
- CountryChina
- Language:Chinese
-
Abstract:
Endemic dental fluorosis has been reported in some regions of the world. China seemed to have high prevalence of endemic dental fluorosis, especially in southwest China. It is now most likely that excessive fluoride intake during enamel development play a key role in the pathogenesis of dental fluorosis. However, excessive intake of fluoride-induced cellular and molecular mechanisms of dental fluorosis are not entirely conclusive. Scholars at home and abroad have made a lot of research on pathogenesis of enamel fluorosis by using various experimental techniques. More recent studies mainly suggest that endoplasmic reticulum stress and calcium overload-associated apoptotic pathway may participate in fluoride excess-evoked pathogenesis of dental fluorosis. Furthermore, the functional changes of enamel matrix protein and protease activity may be involved in the pathological event. This paper summarized the recent research progress on this topic.
