Effect of physiological deep-sea water on the hyperthermal tolerance of mice
10.3969/j.issn.1671-8348.2016.01.012
- VernacularTitle:生理性深层海水对小鼠高温耐受力的影响
- Author:
Youguo DAI
;
Weiming LI
;
Huirong TANG
;
Anhua SHI
;
Ping GAN
;
Yingli CUN
;
Qin LIU
;
Qiongyao GUAN
;
Jin CUI
- Publication Type:Journal Article
- Keywords:
physiological deep-sea water;
hyperthermia,induced;
tolerance
- From:
Chongqing Medicine
2016;(1):33-36
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of physiological deep-sea water(PDSW) on hyperthermal tolerance of Kunming (KM ) mice in the 45 .0 ℃ environment .Methods Deep-sea water from the south Chinese sea was processed ,and the metallic ele-ments dissolved in the DSW were analysed .The mice were randomly divided into 2 groups :the control group received tap water ;the experimental group treated with PDSW for 15 d .And then the mice were fed in the 45 .0 ℃ conditions .The survival time and histo-morphometric analyses of the brain ,lung ,heart ,liver and kidney were investigated .Results The survival time in PDSW-fed group was significantly longer than that of the control group (P< 0 .05) .Moreover ,histomorphometric analyses showed that PDSW could protect the brain ,lung ,heart ,liver and kidney of KM mice from the 45 .0 ℃ conditions .The results of western blot revealed that ex-pression of HSP72 of liver tissues for PDSW-fed group substantially increased ,when compared with the control mice(P< 0 .05) . Conclusion PDSW could improve hyperthermal tolerance of KM mice ,which maybe in the relation with expression of HSP72 pro-moted by PDSW .
