The expression and clinical significance of p53,C-myc and CerbB-2 in thyroid papillary carcinoma
10.3969/j.issn.1671-8348.2016.01.026
- VernacularTitle:p53、C-myc 和 CerbB-2在甲状腺乳头状癌中的表达及临床意义
- Author:
Lu WANG
;
Wenxiu YANG
- Publication Type:Journal Article
- Keywords:
thyroid neoplasms;
adenocarcinoma,papillary;
p53;
C-myc;
CerbB-2;
clinic pathological parameters;
diagnosis,dif-ferential
- From:
Chongqing Medicine
2016;(1):77-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression level and clinical significance of p53 ,C-myc and CerbB-2 in papillary thy-roid carcinoma patients .Methods The expression level of p53 ,C-myc and CerbB-2 were detected in 45 cases of papillary thyroid carcinoma tissue specimens and 45 cases of nodular goiter tissue specimens by using immunohistochemical staining .Their correla-tions with clinic pathological features in papillary thyroid carcinoma were analyzed further .Results The positive expression rates of p53 ,C-myc and CerbB-2 in the papillary thyroid carcinoma tissue specimens were significantly higher than that of the nodular goiter tissue specimens(all P< 0 .01) .The expression of C-myc and CerbB-2 significantly correlated with lymph node metastasis(P< 0 . 05) .The expression of CerbB-2 significantly correlated with tumor size ,local infiltration ,TNM stage ,differentiated degree and lymph node metastasis (all P< 0 .05) .p53 positive expression ,C-myc positive expression and CerbB-2 positive expression were the independent factors of cervical lymph node metastasis .Conclusion p53 ,C-myc and CerbB-2 were highly expressed in papillary thy-roid carcinoma and correlated with cervical lymph nody metastasis .The detection of p53 ,C-myc and CerbB-2 might be helpful for diagnosis of papillary thyroid carcinomas .
