The effects of arsenic on histone modifications
10.3760/cma.j.issn.2095-4255.2016.01.018
- VernacularTitle:砷对组蛋白修饰的影响
- Author:
Dandan LI
;
Yanhui GAO
- Publication Type:Journal Article
- Keywords:
Arsenic;
Histone modifications;
Histone methylation;
Histone acetylation
- From:
Chinese Journal of Endemiology
2016;(1):64-66
- CountryChina
- Language:Chinese
-
Abstract:
Arsenic is one of the important metalloid elements, which is widely distributed in nature. Arsenic can cause many health hazards. However, the toxic mechanisms of arsenic have not yet been fully understood. In recent years, many studies have shown that epigenetic regulation and control mechanism is associated with arsenic toxicity. Histone modification is an important epigenetic regulation and control mechanism, changes in its patterns may be one of the mechanisms by which arsenic alters the gene expression. We reviewed the effects of arsenic on regulation of histone methylation, acetylation, phosphorylation and ubiquitination.
