Roles of autophagy and oxidative stress in arsenic carcinogenesis:a recent advance
10.3760/cma.j.issn.2095-4255.2016.01.019
- VernacularTitle:自噬与氧化应激在砷致癌作用中的研究进展
- Author:
Xinlu LIU
;
Qizhan LIU
- Publication Type:Journal Article
- Keywords:
Autophagy;
Oxidative stress;
Reactive oxygen species;
Arseniasis;
Carcinogenesis
- From:
Chinese Journal of Endemiology
2016;(1):67-70
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy and oxidative stress, which are closely related, play important roles in cellular stress response, defense function, and damage. Arsenic is one of the chemical pollutant, which is widely distributed in natural environment. International agency for research on cancer (IARC) has made it clear that arsenic and its compounds are carcinogens. However, the mechanism of carcinogenesis induced by arsenic still remains obscure. Recently, researchers have found that autophagy and oxidative stress play an important role in the process of arsenic carcinogenesis. In this paper, we have reviewed the types and regulation of cellular autophagy, the roles of autophagy and oxidative stress in tumorigenesis, and the effects of arsenic on carcinogenesis.
