Diagnostic value of 18 F-NaF PET/CT and MRI in detecting skull-base bone invasion of nasopharyn-geal carcinoma
10.3760/cma.j.issn.2095-2848.2016.01.009
- VernacularTitle:18F-NaFPET／CT与MRI在鼻咽癌颅底骨质受侵中的对比研究
- Author:
Yali LE
;
Yu CHEN
;
Yue CHEN
;
Zhanwen HUANG
;
Jingbo WU
;
Dongmei ZHAO
;
Li ZHANG
;
Guangcai TANG
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Skeleton;
Skull base;
Tomography,emission-computed;
Tomography,X-ray computed;
Sodium fluoride;
Magnetic resonance imaging
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2016;(1):34-38
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of 18 F?NaF PET/CT and MRI in the diagnosis of skull?base bone invasion ( SBBI) in patients with nasopharyngeal carcinoma( NPC) . Methods Sixty?three NPC patients (45 males, 18 females;age range 23-72 years) were enrolled in this prospective study. Pa?tients underwent 18 F?NaF PET/CT and MRI to confirm whether the skull base was invaded. The reference standard was based on the follow?up imaging in 6 months. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of the two imaging modalities were calculated. χ2 test was used to analyze their difference. The SBBI foci and their distribution detected by the two imaging modalities were compared. Results Thirty?four NPC patients demonstrated SBBI in follow?up imaging. The diagnostic sen?sitivity, specificity, positive predictive value, negative predictive value, and accuracy of 18 F?NaF PET/CT were 97.1%(33/34), 89.7%(26/29), 91.7%(33/36), 96.3%(26/27) and 93.7%(59/63), respective?ly. For MRI, the parameters were 91.2%(31/34), 86.2%(25/29), 88.6%(31/35), 89.3%(25/28) and 88.9%(56/63), respectively. The diagnostic efficiency of the two imaging modalities had no significant difference (χ2=0.162-1.062, all P>0.05) . 18 F?NaF PET/CT detected 133 lesions and MRI detected 97 le? sions, and the clivus was the most common site of SBBI. Conclusions 18 F?NaF PET/CT and MRI have similar diagnostic efficiency in detecting SBBI. 18 F?NaF PET/CT can detect more lesions than MRI do, and has potential advantage for detecting tiny bone lesions in skull base.
