Research advance in molecular biology of adrenocortical carcinoma
10.3760/cma.j.issn.1000-6699.2016.01.019
- VernacularTitle:肾上腺皮质癌的分子生物学研究进展
- Author:
Luming WU
;
Weiqing WANG
- Publication Type:Journal Article
- Keywords:
Adrenocortical carcinoma;
Steroidogenic factor-1;
Wnt signaling pathway;
MicroRNAs;
DNA methylation
- From:
Chinese Journal of Endocrinology and Metabolism
2016;(1):77-79
- CountryChina
- Language:Chinese
-
Abstract:
[Summary] Adrenocortical carcinoma is a rare disease with poor prognosis, and its pathogenesis is mainly related to genetic mutations, abnormal expressions of steroidogenic factor-1, insulin-like growth factor 2,cell growth factors including vascular endothelial growth factor, dysfunction of Wnt pathway, as well as dysregulation of microRNA and DNA methylation. In recent years, the intensive molecular studies provide a brand-new methodology to distinguish adrenocortical carcinomas from benign tumors in early stage.
