Peripheral blood biomarkers in idiopathic pulmonary fibrosis
10.3760/cma.j.issn.1009-9158.2016.01.017
- VernacularTitle:特发性肺纤维化的生物学标志物检测应用
- Author:
Jie CHEN
;
Nian ZHANG
;
Tianpen CUI
- Publication Type:Journal Article
- Keywords:
Idiopathic pulmonary fibrosis;
Biological markers;
Pulmonary alveoli
- From:
Chinese Journal of Laboratory Medicine
2016;(1):68-70
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown etiology , a median survival time of which is 2 to 3 years.The diagnosis and treatment are important for IPF in time.Krebs von den lungen-6(KL-6), Surfactant protein-A(SP-A) and Surfactant protein-D(SP-D) are acceptable biomarkers in clinical for idiopathic pulmonary fibrosis in Japan,which have shown good sensitivity at diagnosis IPF and predict the prognoses for patients with IPF . However , the differential diagnosis of IPF from other interstitial lung diseases is still challenging .Other biomarkers are being developed , one of which would have the best specificity and sensitivity at diagnosis IPF.Those biomarkers about pathogenesis of IPF includes alveolar epithelial cell dysfunction , fibrogenesis and immune dysregulation are shown .They are potential to account for underlying disease mechanisms , accelerated drug development and advance clinical management.
