Diagnosis and scr eening for antimalarial retinopathy：two cases report and literature review
10.3760/cma.j.issn.1007-7480.2016.01.009
- VernacularTitle:抗疟药视网膜病变的诊断及筛查二例并文献复习
- Author:
Xiaojian JI
;
Bing CHEN
;
Jian ZHU
;
Feng HUANG
;
Jianglin ZHANG
- Publication Type:Journal Article
- Keywords:
Antimalarials;
Retinal disease;
Hydroxychloroquine;
Diagnostic techniques,ophthalmo-logical;
Drug toxicity
- From:
Chinese Journal of Rheumatology
2016;(1):40-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze antimalarial assosiated retinopathy detected by different methods with of modern ocular fundus examination, and explore screening strategy and the diagnosis of hydroxych-loroquine assosiatedretinopathy according to clinical experience and international guidelines. Methods Full fundus examination was performed in two patients with antimalarial retinopathy. The related literature were reviewed. Results Two patients had bull's eyes maculopathy and abnormal visual fields. Conclusion Clin-icians' alertness to hydroxychloroquine related retinopathy may improve early diagnosis of hydroxychloroquine toxicity. New objective tests are more sensitive than visual fields examination. Visible bull's-eye maculopathy is a late change, and the goal of screening is to recognize toxicity at early stage.
