Comparison of accuracy of Marsh model versus Schnider model for propofol target-controlled infu-sion system
10.3760/cma.j.issn.0254-1416.2015.12.015
- VernacularTitle:Marsh参数模型与Schnider参数模型用于异丙酚靶控输注系统准确性的比较
- Author:
Shunsheng CHEN
;
Weiwei LIN
;
Changlian WANG
;
Caizhu LIN
;
Cuihong LIN
- Publication Type:Journal Article
- Keywords:
Propofol;
Drug delivery systems;
Pharmacokinetics
- From:
Chinese Journal of Anesthesiology
2015;(12):1466-1469
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the accuracy of Marsh model and Schnider model for propofol target?controlled infusion ( TCI) system. Methods Eighty patients, aged 20-60 yr, of American Society of Anesthesiologists physical status ⅠorⅡ, with body mass index of 17?5-28?0 kg∕m2 , scheduled for e?lective gynecological operation under general anesthesia, were equally and randomly divided into either Marsh model group ( group M) or Schnider model group ( group S) using a random number table. The target plasma concentration was set at 3 μg∕ml in both groups. During TCI and at different time points after the end of TCI, the blood samples were collected for determination of blood propofol concentrations by high per?formance liquid chromatography with fluorescence detector. The difference between measured and predicted concentrations (△C) at each time point was calculated. The median performance error ( MDPE) , median absolute performance error ( MDAPE) , and wobble of propofol TCI system were calculated in each group. Results In M and S groups, the MDPE was 9. 90% and 14?00%, respectively; the MDAPE was 11?43% and 14?49%, respectively;the wobble was 7?77% and 7?79%, respectively. There was no sig?nificant difference in △C at each time point during TCI between group M and group S (P>0?05). After TCI was stopped, △C at each time point was significantly lower in group M than in group S ( P<0?05) . Conclusion Marsh model provides higher accuracy than Schnider model for propofol TCI system in the pa?tients undergoing gynecological operation.
