Comparison of remifentanil-propofol TCI versus sufentanil-propofol TCI for sedation and analgesia in patients undergoing local anesthesia
10.3760/cma.j.issn.0254-1416.2015.12.017
- VernacularTitle:靶控输注瑞芬太尼和舒芬太尼复合异丙酚用于局部麻醉患者镇静镇痛术效应的比较
- Author:
Xiaowen LIU
;
Xiaoming DENG
;
Chao WEN
;
Ye WANG
;
Lei WANG
;
Jinghu SUI
;
Yulei SUN
- Publication Type:Journal Article
- Keywords:
Analgesics,opioid;
Propofol;
Drug delivery systems;
Conscious sedation;
An-algesia
- From:
Chinese Journal of Anesthesiology
2015;(12):1473-1475
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare remifentanil?propofol target?controlled infusion ( TCI ) with sufentanil?propofol TCI for sedation and analgesia in the patients undergoing local anesthesia. Methods Sixty patients, aged 17?54 yr, with body mass index <30 kg∕m2, scheduled for elective plastic surgery underlocal anesthesia, were equally and randomly divided into remifentanil group (group R) and sufentanil group(group S) by using a random number table. Remifentanil (the initial target plasma concentration 1?? 0ng∕ml) and propofol (the initial target plasma concentration 1?? 0 μg∕ml) were given by TCI in group R.Sufentanil (the initial target plasma concentration 0?? 10 ng∕ml) and propofol (the initial target plasma con?centration 1?? 0 μg∕ml) were given by TCI in group S. The target plasma concentration was adjusted to main?tain the modified Observer′s Assessment of Alertness∕Sedation Scale score of 2 or 3. The occurrence of painresponses, hypoxemia, bradypnea and∕or apnea was recorded during operation. The total amount of propofolconsumed was calculated. Results There was no significant difference in the incidence of pain response,hypoxemia, bradypnea and∕or apnea, and total amount of propofol consumed between the two groups (P >0?? 05). Conclusion Remifentanil?propofol TCI provides similar sedative and analgesic efficacy to that a?chieved by sufentanil?propofol TCI in the patients undergoing local anesthesia.
