Comparison of heated humidified high flow nasal cannula and nasal continuous positive airway pressure for prevention of extubation failure in extremely low birth weight infants
10.3969/j.issn.1673-6710.2016.02.002
- VernacularTitle:不同辅助通气方式预防超低出生体重早产儿拔管失败的临床研究
- Author:
Jia CHEN
;
Fang XU
;
Tao ZHANG
;
Lanlan DU
;
Weiwei. GAO
- Publication Type:Journal Article
- Keywords:
Infant;
extremely low birth weight;
Infant;
premature;
High-flow nasal cannula;
Continuous positive airway pressure
- From:Chinese Journal of Neonatology
2016;31(2):86-90
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the efficacy and safety of heated humidified high flow nasal cannula ( HHHFNC) and nasal continuous positive airway pressure( NCPAP) ventilation for prevention of extubation failure in extremely low birth weight(ELBW)infants in our NICU.MethodsFrom Jan.2011 to Dec. 2014, 129 ELBW infants admitted to our hospital were randomly assigned into HHHFNC group and NCPAP group. The inclusion criteria were gestational age ( GA ) <34 w, birth weight ( BW )<1000 g, admission within 7 d after birth and transition to noninvasive respiratory support after a period of mechanical ventilation with an endotracheal tube. The primary outcome included:the incidence of extubation failure, nasal injury, air leak, abdominal distention and bronchopulmonary dysplasia ( BPD). Results Statistically significant difference sexisted between the two groups on oxygen the rapyduration, the time required reaching total enteral feedings and the incidences of nasal injury, air leak, abdominal & nbsp;distention and necrotizing enterocolitis ( P<0. 05). The incidence of extubation failure within 7 days was 25. 8℅ in HHHFNC group and 47. 6℅ in NCPAP group ( P <0. 05 ) . No differences between the 2 groups on total ventilation duration, non-invasive ventilation duration, re-intubation rate at 3d after extubation, BPD, retinopathy of prematurity ( ROP ) , intracerebral hemorrhage ( ICH ) , periventricular leukomalacia(PVL)and patent ductus arteriosus(PDA).Conclusions HHHFNC is an effective and safe method for prevention of extubation failure in ELBW infants.
