Therapeutic Efficacy of Lactulose Combined with Bacillus subtilis and Enterococcus faecium Preparation on Chronic Constipation
10.3969/j.issn.1008-7125.2016.02.006
- VernacularTitle:乳果糖联合枯草杆菌二联活菌治疗慢性便秘的疗效
- Author:
Xiaoling WU
;
Yibo HE
;
Yumei WU
- Publication Type:Journal Article
- Keywords:
Constipation;
Lactulose;
Bacillus subtilis and Enterococcus faecium Prearation;
Therapy
- From:
Chinese Journal of Gastroenterology
2016;21(2):90-92
- CountryChina
- Language:Chinese
-
Abstract:
Background:The incidence of chronic constipation is increasing in recent years,which seriously affects the quality of life of patients. Aims:To investigate the therapeutic efficacy of lactulose combined with Bacillus subtilis and Enterococcus faecium preparation on chronic constipation. Methods:A total of 112 patients with chronic constipation from Jan. 2011 to Jan. 2014 at Emeishan Hospital of TCM were enrolled,and were randomly divided into observation group and control group. Patients in both groups accepted the guidance of diet. In addition,patients in control group were orally administrated with lactulose while patients in observation group were orally administrated with lactulose combined with Bacillus subtilis and Enterococcus faecium preparation. After 4 weeks of treatment,therapeutic efficacy in the two groups was compared,patient assessment of constipation quality of life scale(PAC-QOL)was used to evaluate the quality of life. Results:The overall therapeutic efficacy rate in observation group was significantly higher than that in control group (98. 2% vs. 72. 2% ;χ2 = 12. 399,P < 0. 05). Score of every factor and the total score of PAC-QOL were significantly lower after treatment than those before treatment in both groups(P < 0. 05),while physical discomfort score and the total score in observation group were significantly lower than those in control group( P < 0. 05). Conclusions:Lactulose combined with Bacillus subtilis and Enterococcus faecium preparation can effectively improve the symptoms of difficulty in defecation,hard stool,and improve the quality of life in patients with chronic constipation.
