Investigation on Relationship between Different Helicobacter pylori Antibodies and Gastric Cancer,Peptic Ulcer and Chronic Gastritis in Xinjiang Area
10.3969/j.issn.1008-7125.2016.02.009
- VernacularTitle:幽门螺杆菌不同抗体与新疆地区胃癌、消化性溃疡和慢性胃炎的关系
- Author:
Xinguo WANG
;
Li LI
;
Feng GAO
- Publication Type:Journal Article
- Keywords:
Stomach Neoplasms;
Peptic Ulcer;
Gastritis;
Helicobacter pylori;
CagA Antibody;
VacA Antibody;
Urease Antibody;
Risk Factors
- From:
Chinese Journal of Gastroenterology
2016;21(2):101-103
- CountryChina
- Language:Chinese
-
Abstract:
Background:Helicobacter pylori( Hp)is the main cause of chronic gastritis( CG),and CagA and VacA are important pathogenic factors of Hp. Recent studies have indicated that CagA and VacA antibodies of Hp have close relationship with gastric cancer(GC)and peptic ulcer(PU). Aims:To investigate the relationship between different antibodies of Hp and GC,PU and CG in Xinjiang area. Methods:Eighty-four GC,108 PU and 196 CG patients from Jan. 2014 to Aug. 2014 were enrolled. 14 C-urea breath test was used to determine Hp infection. Hp was typed by immunoblotting technique. Relationship between different Hp antibodies and patients with GC,PU and CG was analyzed. Results:Type Ⅰ Hp-positive rate in GC,PU and CG groups was decreased stepwisely(47. 6% ,37. 0% ,21. 4% , respectively). The positive rates of Hp strains(CagA-128 kDa,VacA-110 kDa and UreB-66 kDa)differed significantly among GC,PU,and CG groups(P = 0. 013,P = 0. 011,P = 0. 002);GC was associated with CagA-128 kDa,VacA-110 kDa,VacA-90 kDa and UreB-66 kDa(P < 0. 05),PU was associated with VacA-110 kDa,UreB-66 kDa(P < 0. 05). UreB-66 kDa was the risk factor of PU and GC(P < 0. 05). Conclusions:GC is associated with CagA-128 kDa,VacA-110 kDa,VacA-90 kDa and UreB-66 kDa,PU is associated with VacA-110 kDa,UreB-66 kDa,and UreB-66 kDa is the risk factor of PU and GC.
