Research Progress of Peripheral Blood Circulating Tumor Cells in Digestive System Tumors
10.3969/j.issn.1008-7125.2016.02.011
- VernacularTitle:消化系统肿瘤外周血循环肿瘤细胞的研究进展
- Author:
Shaojun SHI
;
Feng XUE
- Publication Type:Journal Article
- Keywords:
Neoplastic Cells,Circulating;
Digestive System Neoplasms;
Neoplasm Metastasis;
Prognosis
- From:
Chinese Journal of Gastroenterology
2016;21(2):107-110
- CountryChina
- Language:Chinese
-
Abstract:
Recently,the detection of circulating tumor cells(CTCs)in peripheral blood is used in clinical practice as a form of‘ liquid biopsy’. The self-seeding mechanism of CTCs provides a novel approach to explore the growing mechanism of malignant tumor and developing corresponding targeting therapies. A decade ago,the CellSearch system, which can capture and enumerate CTCs,has been validated by Food and Drug Administration( FDA)as an aid for monitoring the relapse of tumor after radical operation in patients with breast,prostate and colorectal cancer. In recent years,although the separation and detection technique of CTCs has been promoted significantly,the clinical significance of CTCs in tumors of digestive system is still under investigation. This article reviewed the research progress of peripheral blood CTCs in digestive system tumors.
