Treatment Strategy for Chronic Hepatitis B Virus Infection with Normal Alanine Aminotransferase
10.3969/j.issn.1008-7125.2016.02.001
- VernacularTitle:丙氨酸氨基转移酶正常的慢性乙型肝炎病毒感染治疗策略
- Author:
Yang DING
;
Xiaoguang DOU
- Publication Type:Journal Article
- Keywords:
Alanine Transaminase;
Hepatitis B Virus;
Immune Tolerance;
Therapy
- From:
Chinese Journal of Gastroenterology
2016;21(2):65-68
- CountryChina
- Language:Chinese
-
Abstract:
Different subtypes of chronic hepatitis B virus(HBV)infection occurred clinically because of the status of virus’s interaction with immune system. In patients with immune tolerance,high level of HBV DNA was found,serum hepatitis B e antigen(HBeAg)was positive,and serum level of alanine aminotransferase(ALT)was normal with only mild or no inflammation in liver tissue. However,not all the patients with normal ALT were in immune tolerance status,the disease could progress insidiously and develop into liver cirrhosis. Whether these patients need anti-viral therapy has always been a hotspot of study. This article reviewed the correlation between immune status and HBV infection,the identification of patients with normal ALT but not in immune tolerance status,and the indication of anti-viral therapy for these patients.
