Efficacy of EUS-guided ethanol ablation in the treatment of insulinoma
10.3760/cma.j.issn.1007-5232.2016.02.002
- VernacularTitle:内镜超声引导下无水乙醇注射治疗良性胰岛素瘤的疗效分析
- Author:
Shanyu QIN
;
Zhiling LIU
;
Haixing JIANG
;
Wei LUO
;
Bangli HU
;
Hongjian NING
;
Lin TAO
;
Sibiao SU
;
Fengyan QIN
- Publication Type:Journal Article
- Keywords:
Insulinoma;
EUS;
Alcohol injection;
Efficacy
- From:
Chinese Journal of Digestive Endoscopy
2016;33(2):72-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and efficacy of endoscopic ultrasonography(EUS) guided ethanol ablation in patients with insulinoma. Methods The data of 10 patients with insulinoma trea-ted at the First Affiliated Hospital of Guangxi Medical University from December 2013 to January 2015 were prospectively analyzed. Results The patients were given EUS-guided ethanol ablation with dose of 0. 10 to 2. 00 ml(average 0. 70 ± 0. 62 ml)in pancreatic lesions for 15 times. No complications were observed dur-ing and after the procedure. The blood glucose improved after the procedure[4. 8(3. 9-5. 5)mmol/ L VS 2. 4 (1. 9-2. 5)mmol/ L,P < 0. 05]and the serum insulin level significantly decreased[83. 7(40. 1-143. 5) pmol/ L VS 177. 3(66. 5-200. 6)pmol/ L,P<0. 05]. The average hospital stay was(4. 3±1. 5)days. The patients were followed up for 6-12 months. EUS indicated that the echo of pancreatic lesions changed from high to low. CE-EUS revealed low enhancement and lack of blood supply. Conclusion EUS-guided ethanol ablation may become a promising minimally invasive treatment for insulinoma because of its safety,efficacy and low price. Trail registration Clinical Trial.gov,NCT02121366.
