Evaluation on biocompatibility of carbon-fiber-reinforced polyether-ether-ketone after implantation in rabbit models with single bone cortex defect of mandibula
10.13481/j.1671-587x.20140321
- VernacularTitle:碳纤维增强型聚醚醚酮植入下颌骨单层骨皮质缺损模型白兔体内后的生物相容性评价
- Author:
Rui LIU
;
Minghe LI
;
Xin JI
;
Chengmin HAN
- Publication Type:Journal Article
- Keywords:
polyetheretherketone;
carbon fiber;
biocompatibility;
bone defect
- From:
Journal of Jilin University(Medicine Edition)
2014;(3):569-573
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanical properties of carbon-fiber-reinforced polyether-ether-ketone (CF/PEEK)composite materials and to evaluate the biocompatibility and bioactivity of CF/PEEK after implanted into mandibula.Methods 27 adult Japanese white rabbits were randomly divided into experimental group (n=9) and control group (n=18),CF/PEEK was implanted into bilateral mandibula of the rabbits in experimental group, autologous bone was implanted into left mandibula of the rabbits in positive control group (n=9 )while the right sides were taken as blank control group (n=9 )without implants. The materials-bone interface of samples were collected to make the observation of gross,imaging and histology and to analyze the histological score after 8,12, and 16 weeks.Results All the animals and no infection had secondary fractures.Obviously callus formation was observed on the edge of the defect in both experimental group and positive control group in the imaging observation, while the rabbits in blank control group had no obvious change.Compared with 8 weeks after operation, the score evaluation of local cellular immune response showed significant decreasing in 12 weeks after operation(P<0.01), the data was the minimum in 16 weeks(P<0.05).At the same time,the score evaluation of local cellular immune response in three groups showed no significant difference (P> 0.05).Trabecular bone and osteoblasts could be observed in the bone defect of both experimental group and positive control group after 16 weeks,and blank control group was filled with fibrous connective tissue.The osteogenesis rates in experimental group and positive control group were increased with the prolongation of time, and they were better than that in blank control group (P<0.01).Conclusion CF/PEEK material has good mechanical property,biocompatibility and bioactivity;and it has light immune response after implantation.
