Application value of urinary lactate/creatinine ratio in prognosis evaluation of neonatal asphyxia
10.13481/j.1671-587x.20140338
- VernacularTitle:尿乳酸／肌酐比值在新生儿窒息预后评估中的应用价值
- Author:
Xiaodan LIU
;
Yuxian GAO
;
Jing REN
;
Minmin ZHANG
;
Chaoying YAN
- Publication Type:Journal Article
- Keywords:
neonatal asphyxia;
lactic acid;
lactate-acetyl-β-D-glucosaminidase;
creatinine
- From:
Journal of Jilin University(Medicine Edition)
2014;(3):655-658
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between urinary lactate/creatinine ratio and neonatal asphyxia,and to clarify the application value of urinary lactate/creatinine ratio in forecasting the hypoxie-ischemic encephalopathy (HIE)in neonates.Methods Using case-control study design method,40 cases of neonatal asphyxia infants were selected as asphyctic group and 40 healthy infants were used as control group.The urinary lactate/creatinine ratio in the first day after birth, urinary N-Acetyl-β-D-glucosaminidase (NAG)/creatinine and the score of Apgar of 80 infants were detected.The relationship between the urinary lactate/creatinine ratio,urinary NAG/creatinine ratio, as well as the score of Apgar and HIE were analyzed and compared in asphyctic group and control group.Results The Apgar scores at 1 and 5 min in asphyctic group were significantly lower than those in control group (P<0.01). The urinary lactate/creatinine ratio and urinary NAG/creatinine ratio in asphyctic group 1 d after birth were significantly higher than those in control group(P<0.01).There was significantly negative correlation between the urinary lactate/creatinine ratio and the 1-min and 5-min Apgar scores(r=-0.636,P<0.001;r=-0.883,P<0.01),but there was a significantly positive correlation between the urinary lactate/creatinine ratio and urinary NAG/creatinine ratio(r=0.433,P<0.01).Conclusion The urinary lactate/creatinine ratio may have decisive roles in prognosis evaluation of neonatal asphyxia,and so as the important foundation for the prediction of HIE.
