Effect of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction of middle cerebral artery stenosis
10.3760/cma.j.issn.1008-6706.2016.07.016
- VernacularTitle:阿司匹林联合氯吡格雷治疗大脑中动脉狭窄脑梗死的有效性
- Author:
Houming YU
;
Yichao YU
;
Xiaoping ZHANG
- Publication Type:Journal Article
- Keywords:
Cerebral infarction;
Aspirin;
Clopidogrel
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(7):1018-1021
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of aspirin combined with clopidogrel in the treatment of patients with cerebral infarction of middle cerebral artery stenosis.Methods 88 patients with cerebral infarction of middle cerebral artery stenosis were selected and divided into group A and B based on the methods of treatment,44 patients in each group.Patients in group A were given aspirin, and patients in group B were given aspirin combined with clopidogrel.The effects of the group A and B were observed and compared.Results The total effective rate of group B was 90.91%,which was higher than 75.00%(33/44) of group A,the difference was statistically significant(χ2 =3.938,P<0.05).The progression rate and relapse rate of group B were 6.82%and 4.55%,which were lower than 27.27%and 20.45%of group A,and the differences were statistically significant(χ2 =7.639,5.091,all P<0.05). The scores of modified Barthel Index and modified Fugl-Meyer in group B were all better than the scores in group A after treatment,and the differences were statistically significant(all P<0.05).Conclusion It is effective for aspirin combined with clopidogrel to treat the patients with cerebral infarction of middle cerebral artery stenosis,which can decrease the rate of progression and relapse,and worthy of clinical application.
