Effect of improving nursing evaluation and implementation on the quality of life in patients with advanced non small cell lung cancer
10.3760/cma.j.issn.1008-6706.2016.05.005
- VernacularTitle:完善护理评价与贯彻体系对晚期非小细胞肺癌患者生存质量的影响研究
- Author:
Hongqin ZHOU
- Publication Type:Journal Article
- Keywords:
Cancer,non small cell lung;
Perfect nursing evaluation and implementation system;
Tumor marker;
Quality of life
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(5):657-662
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of improving nursing evaluation system on the quality of life in patients with stage Ⅲ and Ⅳ stage non small cell lung cancer (NSCLC).Methods From January 2011 to December 2014,100 patients with NSCLC were randomly divided into observation group and control group , 5 0 cases in each group.The observation group was treated with 1 month as a treatment course.The control group was treated with rou-tine treatment and nursing.Before treatment and 2 months after treatment,serum tumor markers (CEA,CYFRA21 -1,NSE,CA125) were detected,the clinical symptom score,quality of life (KPS score) and body weight were recor-ded.Results (1)The total effective rates of the observation group and the control group were 88% and 90% respec-tively,the difference was not statistically significant (χ2 =0.381,P >0.05);(2)There were no significant differences in the clinical symptoms between the two groups (t =0.382,1.521,all P >0.05) before and after intervention.After intervention,the clinical symptoms of the two groups were lower than before intervention,the difference was statistical-ly significant (t =6.493,4.398,all P <0.05);Before intervention,there was no significant difference in KPS score and body weight between the two groups (t =1.483,2.480,all P >0.05);After 6 months of intervention,the KPS score and body weight of the observation group were significantly higher than those in the control group,the differences were statistically significant (t =5.493,4.326,all P <0.05);(3)In the observation group and the control group,the median PFS was 5.93 months (1.67,12.87),6.21 months (1.55,14.12);the median OS was 16.24 months (3.87,26.49) and 17.09 months (4.02,29.33),the differences were not statistically significant between the two groups(t =0.942,1.843,all P >0.05);(4) Before the intervention,there were no significant differences in serum tumor markers (t =0.483,1.264,1.762,1.264,1.795,1.678,1.253,1.469,all P >0.05);After intervention,ser-um markers in the two groups were significantly lower than before intervention,the differences were statistically signifi-cant (t =6.393,3.490,4.728,7.943,4.883,5.478,7.684,11.383,all P <0.05);After intervention,there was no significant difference between the two groups (t =1.456,1.548,1.559,1.259,1.895,0.639,0.248,1.127,all P >0.05).Conclusion For patients with stage III,IV NSCLC,improving nursing evaluation and implementation system has no significant difference in reduce the level of tumor markers and long -term survival compared with the control group,and improve the nursing evaluation and implementation system has certain advantages in maintaining the quality of life of patients.
