Study of the efficacy and toxicity of gemcitabine combined with nedaplatin in anthracycline and/or taxane -pretreated patients with metastatic triple -negative breast cancer

VernacularTitle:吉西他滨联合奈达铂治疗蒽环类和／或紫杉类耐药的转移性三阴乳腺癌疗效观察
Author: Xiaoyu SHI ; Jing ZHANG ; Wei MENG ; Likun SUN ; Junfeng ZHAO
Publication Type:Journal Article
Keywords: Breast neoplasms; Tumor metastasis; Gemcitabine; Nedaplatin
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(5):712-715
CountryChina
Language:Chinese
Abstract: Objective To evaluate the short -term efficacy and adverse reactions of gemcitabin combined with nedaplatin to patients with metastatic triple -negative breast cancer after taxane and/or anthracycline treatment. Methods Thirty -three patients with anthracycline and/or taxane -resistant metastatic triple -negative breast cancer received gemcitabin and nedaplatin regimen:gemcitabin 1 000 mg/m2,d1,8 days,intravenous;nedaplatin 80mg/m2,d1,intravenous.Treatments were repeated every 21 days and response rate was evaluated every two cycles. Results Of 33 patients, complete remission ( CR) in 1 case ( 3.03%), partial remission ( PR) in 13 cases (39.39%),stable disease(SD) in 11 cases(33.33%),progressive disease(PD) in 8 cases(24.24%),objective response rate was 42.42%.The main adverse reaction was bone marrow suppression and gastrointestinal reaction. Conclusion Combination therapy of gemcitabin and nedaplatin is an effective and well tolerated rescue regimen in anthracycline and/or taxane -resistant metastatic triple -negative breast cancer patients.