Clinical observation of recombinant human interleukin-11 combined with prednisone in the treatment of adult recurrent primary immune thrombocytopenia
10.3760/cma.j.issn.1008-6706.2016.06.001
- VernacularTitle:重组人白细胞介素11联合泼尼松治疗成年人复发性免疫性血小板减少症临床观察
- Author:
Yunlong LI
;
Chengwang JING
;
Dejun HUANG
;
Ying ZHANG
- Publication Type:Journal Article
- Keywords:
Recombinant human interleukin-11;
Prednisone;
Thrombocytopenia,immunity;
Adult
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(6):801-804
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect and adverse reaction of recombinant human interleukin-11 ( rhIL-11) combined with prednisone in the treatment of adults with recurrent primary immune thrombocytopenia ( ITP) .Methods The clinical and laboratory data of 34 patients of adult recurrent ITP were retrospectively analyzed.16 cases in A group were treated with prednisone,18 cases in B group were treated with rhIL-11 combined with prednisone.Results The effective rate of B group was 44.5%,which of A group was 50.0%,there was no sig-nificant difference between the two groups(P>0.05).After 7d,10d,14d treatment,platelet count in B group were (39.7 ±16.3) ×109/L,(55.3 ±27.6) ×109/L,(71.8 ±30.9) ×109/L respectively,which in A group were (24.3 ±6.7) ×109/L,(35.6 ±28.6) ×109/L,(47.3 ±29.2) ×109/L respectively,the differences between the two groups were statistically significant(t=2.008,2.090,2.431,all P<0.05).There were 5 cases(31.3%) in A group and 6 cases(33.3%) in B group showed adverse reactions,the difference between the two groups was no signif-icant (χ2 =2.117,P>0.05%),but there were 2 cases of capillary leak syndrome(CLS) in B group.Conclusion rhIL-11 combined with prednisone can promote significant rebound of platelet in the adult patients with recurrent IPT in a short term,effectively control bleeding,and the side effect is controllable.
